Santa Clara is home to a mausoleum. which houses the remains of Che Guevara and sixteen of his fellow combatants killed in 1967 during the Bolivia campaign.At the site, there is a museum dedicated to Guevara's life.

In Santa Clara's center is a park called Parque Vidal by the locals and it is laid on an entire square block.

There is a statue of Marta Abreu in the park, a person much loved by the people of Santa Clara.

Santa Clara is probably one of the most traditional places in Cuba.